HELLO CUPCAKE ITS ME

My Battle With Depression, Weight loss, and Diabetes

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Showing posts with label Progress. Show all posts
Showing posts with label Progress. Show all posts

What side are your lines?

Mine will be on my left. I will also have some on the right. Those lines will be hearts and stars, signifying that the hopes and dreams of those suffering will one day come true.

Researchers Isolate Protein Linking Exercise to Health Benefits

A team led by researchers at Dana-Farber Cancer Institute has isolated a natural hormone from muscle cells that triggers some of the key health benefits of exercise. They say the protein, which serves as a chemical messenger, is a highly promising candidate for development as a novel treatment for diabetes, obesity and perhaps other disorders, including cancer.

Bruce Spiegelman, PhD, a cell biologist at Dana-Farber, is senior author of the report, posted as an advanced online publication by the journal Nature. The first author is Pontus Bostroöm, MD, PhD, a postdoctoral fellow in the Spiegelman lab.

"It's exciting to find a natural substance connected to exercise that has such clear therapeutic potential," said Bostroöm.

Spiegelman dubbed the hormone "irisin," after Iris, a Greek messenger goddess. He said the discovery is an important first step in understanding the biological mechanisms that translate physical exercise into beneficial changes throughout the body, both in healthy people and in preventing or treating disease.

"There has been a feeling in the field that exercise 'talks to' various tissues in the body," said Spiegelman, a professor of cell biology at Harvard Medical School. "But the question has been, how?"

According to the report, the irisin hormone has direct and "powerful effects" on adipose, or fatty, tissue -- subcutaneous deposits of white fat that store excess calories and which contribute to obesity.

When irisin levels rise through exercise -- or, in this study, when irisin was injected into mice -- the hormone switches on genes that convert white fat into "good" brown fat. This is beneficial because brown fat burns off more excess calories than does exercise alone.

Only a small amount of brown fat is found in adults, but infants have more -- an evolutionary echo of how mammals keep themselves warm while hibernating. In the wake of findings by Spiegelman and others, there has been a surge of interest in the therapeutic possibilities of increasing brown fat in adults.

Along with stimulating brown fat development, irisin was shown to improve glucose tolerance, a key measure of metabolic health, in mice fed a high-fat diet.

The discovery won't allow people will be able to skip the gym and build muscles by taking irisin supplements, Spiegelman cautioned, because the hormone doesn't appear to make muscles stronger. Experiments showed that irisin levels increase as a result of repeated bouts of prolonged exercise, but not during short-term muscle activity.

The Dana-Farber team identified irisin in a search for genes and proteins regulated by a master metabolic regulator, called PGC1-alpha, that is turned on by exercise. Spiegelman's group had discovered PGC1-alpha in previous research.

Bostroöm said the hunt for molecular targets of increased PGC1-alpha activity ultimately pinpointed irisin, which turned out to be located within the outer membrane of muscle cells. This discovery ran counter to other scientists' contentions that such a protein would reside in the cell's nucleus.

To test whether increasing irisin alone could mimic exercise benefits, the scientists injected modest amounts into sedentary mice that were obese and pre-diabetic.

With 10 days of treatment, the mice had better control of blood sugar and insulin levels -- in effect, preventing the onset of diabetes -- and lost a small amount of weight. Although the weight loss was small, Spiegelman said that the hormone may have a greater effect when given for longer periods.

There were no signs of toxicity or side effects, which was predicted since the researchers limited the increase of irisin to levels typically caused by exercise.

In part because it is a natural substance and because the mouse and human forms of the protein are identical, Spiegelman said it should be possible to move an irisin-based drug rapidly into clinical testing -- perhaps within two years.

The irisin discovery has been licensed by Dana-Farber exclusively to Ember Therapeutics for drug development. Ember is a Boston-based startup co-founded by Spiegelman and scientists at the Joslin Diabetes Center and the Scripps Research Institute in Florida.

The scientists said their findings merely scratch the surface of irisin's multiple effects. They are continuing to explore the hormone's possible benefits in metabolic diseases like diabetes, insulin resistance, and obesity, which constitute a growing epidemic around the world, as well as neurodegenerative illnesses like Parkinson's disease.

Spiegelman added that as growing evidence implicates obesity and physical inactivity in cancer development, it's conceivable irisin-based drugs may have value in prevention and treatment of the disease.

Doctor Not Happy

Well I had to get established with my new Dr. the other day and so she wanted to run a blood panel on me to see what's going on under the hood. We had our initial talk about what I was looking for in a doctor, and what she could help with and what she had to offer.

So I get my blood drawn and the next day I get a phone call “Hello Mr. Peterson, I am calling from Dr. Hongs office and I wanted to go over the results of your blood work. Your blood sugars were really high, but I suppose you already knew that. Your Cholesterol is high, same with your triglycerides and Dr. Hong wants to start you on some medications to help with that, and she also noticed that your Thyroid levels are not where they should be. We would like to have you come back in for some additional blood work.”

Well I will have to say that I am quite interested that my Thyroid is acting up, since I have been screeching at doctors for a while now that my weight problem may be an issue with my thyroid. We shall see what this next round of testing holds.

Big Blue Test Nov 1 - 14

What Is Big Blue Test?

The Big Blue Test is a diabetes awareness program started by the nonprofit Diabetes Hands Foundation, that takes place every November leading up to World Diabetes Day on Nov. 14. The campaign reinforces the importance of exercise in managing diabetes. People with diabetes are encouraged to do the Big Blue Test any day between November 1 and November 14 at midnight Pacific Time, by testing their blood sugar, getting active, testing again, and sharing the results online at bigbluetest.org.

In the last two years, just 14 minutes of exercise decreased participants’ blood sugar level between 15 and 20 percent.

In 2010, more than 2,000 people did the Big Blue Test. Over 120,000 people watched the Big Blue Test video. Roche Diabetes Care, makers of ACCU-CHEK® diabetes products and services, funded the production of the video and helped it go viral by donating 75 cents for each of the first 100,000 views, resulting in total donation of $75,000. The donation provided insulin and supplies to more than 2,000 people with diabetes in developing countries.

In 2011, in connection with the number of people that do the Big Blue Test, another donation from Roche Diabetes Care will benefit more than 8,000 people with diabetes in need. Five nonprofit organizations focused on helping underserved areas with a high incidence of diabetes in the United States will each receive $10,000, while $25,000 will go to support the work in Latin America by the International Diabetes Federation’s Life for a Child Program.

Big Blue Test is once again sponsored by Roche Diabetes Care,
makers of ACCU-CHEK® products and services

Big Blue Test

Blood Work, and Diabetes Check up

Well the doctor has found that I have Low Testosterone which may be some of the cause for my depression, though he is not totally confidant that is the only factor….

So we are going to undergo more testing. We are also going to be tweaking my medications to see if that will help any.
My Diabetes Educator was really happy with the results that I brought in today, and was happy to see that I was journaling again. I had also brought in My Fitness Pal reports and showed her the progress that im making there.
She was thrilled and wants me to attend a Diabetic Support group later this month, and share my knowledge about the different programs that are out there for free that can help others in the community. So I need to put together a resource flyer so that they have everything that I have.

It is strange that by helping others I help myself. When Im not working on others I am not working on myself…I wonder what this is all about, perhaps this is something new for me to explore with my councilor. 

Well Im trying to do better, today I remembered to take all my medications, including my insulin. I also have updated my account over at www.myfitnesspal.com and even ended the day out with 781 Calories left, plus did 15 minutes of walking.

www.myfitnesspal.com

Created by MyFitnessPal - Free Calorie Counter

I have started a new program called myfitnesspal.com I am going to try and get back on track with everything. So here goes, starting Monday 7/18

Mfpiphone Reach your weight loss goals with MyFitnessPal, the best calorie counter on the iPhone. Set a daily calorie goal, then record your daily food and exercise to make sure you stay on track. Then watch the pounds come off!

Our iPhone app gives you full mobile access to your MyFitnessPal.com account, so you can log your food and exercise from anywhere, at any time. All changes made on your iPhone will be synchronized with our website and vice versa.

Best of all, both the iPhone app and our website are 100% FREE! So don't wait - start changing your life today.

Get MyFitnessPal from the App Store

 

 

 

And so it begins….

So the race has once again started. I told myself that after the holidays and after I got settled back in that I would be picking up where I left off. I don’t have a weigh in right now I wont get that until tomorrow when I check in with my Diabetes Educator.

I know that I probably have done more damage to myself than good, but I am willing to face this self induced problem and hit the ground running. Last week I did no other exercise than clean my room and rearrange it, which normally would have taken someone only a few hours, it too me several days and I am not completely done as of yet. I am counting this as exercise as there was a lot of bending, and lifting involved.

This also now means that I will be returning to the way I was eating, but this time im going to try and work on portion controls, to see if that will help jump start my efforts too.

Also I heard of a new homeopathy thing that is suppose to help, you are suppose to drink a glass of warm to hot water with lemon juice in it, every morning to supercharge fat break down and metabolism.

Thanksgivings over now Christmas

apple pie

Image by Kanko* via Flickr




Well I hope you all had a great Thanksgiving. This year was the first year that we had a sugar free meal, and I have to say that the taste was not lacking as many had thought that they might.

We had Apple Pie made with Swee-D-Pie Pie Fillings which was a real big hit with the family, and a sugar free pumpkin pie which was very moist and just as good as any other.

So after having ate so much that it made me almost sick, I am looking forward to monday when I will resume my exercises to work off the feast.

Christmas which is now right around the corner is another time for great meals and over eating. If you do partake in the holiday meals, feel free to reward yourself but dont forget your need for watching sugars and getting back into the swing of working out.

Getting back on track

running-track[1] Getting back on track is something that is really hard to do, and in a way I know that I should have never taken any time off from my regiment.

I had taken four weeks off of doing my day to day exercises, and now that I am trying to get back into the groove of things I am finding it way harder then what it was when I first started out.

My monthly Glucose Levels

EPSON009

Well I have to say that last months glucose levels were pretty good, there were a few high spikes, but not on a daily like they were the month before.

You will see that the blue line spikes way up to 550. Well that day I was under a huge amount of stress, and didn’t take my shot for a day and a half, and that was the result. But they still looked really good across the board. This graph was created by SoundTells Glucose Tracker find it in the download section of this blog.

Transplanted Feces Improve Insulin Sensitivity

 

6914[1]

European researchers have reported that when fecal matter transplanted from healthy and thin people to obese people with pre-diabetes, insulin sensitivity of the latter group increased. (Insulin sensitivity is the body's ability to use insulin properly to regulate the amount of glucose in the blood. The pre-diabetes occurs when the increasing insulin resistance creates higher than normal glucose, a prerequisite for the emergence of full-fledged type 2 diabetes.)

The team of researchers led by Anne Vriezen, MD, Academic Medical Center Amsterdam, The Netherlands, focused on 18 overweight men aged 21-65 years who were diagnosed with metabolic syndrome. (The term that describes a set of conditions that are often used interchangeably with pre-diabetes). The men were not taking medication for their condition and had not received antibiotics within the past 90 days. After the intestines of men have been thoroughly cleaned, feces were transplanted into people who were either male donors thin, or control, in the feces that they themselves produced. The two sources of feces were tested for parasites and pathogens.

During the six-week experiment, neither group experienced a weight loss, an effect seen in animal experiments. But the peripheral insulin sensitivity was significantly improved in men who received transplantation or by external donors and those who were implanted with their own feces. Vrieze attributed the increase to the effects of transplantation because there had been no change in the power of men or physical activity. Although the study results are promising, the use of gut bacteria affect pre-diabetes program is still in very early stage of research. fecal transplant is not a new line of research, but Vrieze is the first study to focus on the possible effects of fecal transplant in metabolic syndrome. Previous studies had focused on the use of stool to restore and rebalance the intestinal bacteria of laboratory animals and humans.

Several medical centers in the United States focused on fecal transplantation as a possible treatment for people with persistent gastrointestinal infections caused by Clostridium difficile Scanning electron micrograph of Clostridium di.... In such cases, the system of "good" bacteria is destroyed by gastrointestinal antibiotics in medical treatment, leaving open the digestive tract to the overcrowding of the robust, resistant to antibiotics difficile Clostridium. The introduction of fecal matter in patients introduces new bacteria that reproduce rapidly, reducing the number of Clostridium difficile. Their presence reduces bloating and diarrhea often associated with Clostridium difficile.

Small size and limited duration of the study Vriezen, the connection planted fecal matter and increased insulin sensitivity is indicative but not conclusive. The results open the door to much larger studies and longer, trying to demonstrate that the differences between individuals with the intestinal biota, the products of genetics and family environment, can become a tool for diabetes. While researchers continue to examine the bacteria in the digestive system a key factor in the progression of diabetes treatment aims to modify the intestinal biota does not seem so implausible, because it would have only a few years ago.

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Insulin Shot Record Week 8

shot-record-week-8

Here is my record for this last week. Still not getting this stupid thing filled out the way I should, maybe some day.



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Pedometer Week Progress 8

pedometer-week-8

Well I am impressed. I forgot to wear my meter for 2 days and I was only off by 2 miles this week.

I still dropped my next weeks goal to 15 miles.



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Food Diary Week 9

food diary week 9

I didn’t eat well this week. There was a lot of days where I didn’t eat meals on regular basis.

As a result for my wacky eating my glucose levels where all over the place.



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Pedometer Progress week 7

pedometer week 7 Well I was able to make my 20 mile mark + 3 additional miles.

I am finding that it is easier for me to make 15-20 miles a week verse’s anything else. So I think that I’m going to keep my distance between those ranges until spring.

I did really well on my mileage on Saturday, but that is because I went shopping which you tend to do a lot of walking around. But still every little bit helps.

Insulin Shot Record Week 7

shot record week 7 This week I missed one day of insulin, which I know is a bad thing.

However I did get my full shot requirement in on at least two days. And on Sunday I got 4 testing’s done, and only missed 1 day of testing.

I have also gotten at least two sets of glucose readings one in the morning and one at night.

There are two days where my blood sugar level was above 350, and that was Monday (352) and Friday (409). These were junk food day’s which I have been good about not doing, but you have to slip every now and then, but you sure do pay for it in the end!

Food Diary Week 8

food diary week 8

Well this week I tapered off the Mc Donnalds, still hit them up twice this week.

I also noticed that my carb intake was pretty heavy this week. Which could explain some of the high glucose levels that I’ve had last week.

Lets see how this week goes!

Pedometer Week 6

pedometer week 6

I am pleased to announce that I made my goal of 15miles worth of walking and did even more by doing almost 26 miles.

I am super excited. But as the weather here in the great North West is becoming more wet and cold, I really dont know how much longer I can keep up with it.

I am however going to continue to keep up the hard work. I only have 169 lbs left to lose, and I am making great progress. I believe that I will obtain my goal of 225-250 by July 2012.

Shot Record Week 6

shot record week 6

I have been under a ton of stress this last week which is a result of the high glucose levels.

I have tried getting in the requested 3 shots that my Diabetes Educator wanted me to, but it is really hard to do for me.

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