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Showing posts with label amputation. Show all posts
Showing posts with label amputation. Show all posts

Lower Limb Amputation Rates Associated With Diabetes Drop, US

An investigation by the Centers for Disease Control and Prevention, found that between 1996 and 2008, the number of leg and foot amputations among U.S. individuals, aged 40+ with diagnosed diabetes, decreased by 65%.
The study, entitled "Declining Rates of Hospitalization for Non-traumatic Lower-Extremity Amputation in the Diabetic Population Aged 40 years or Older: U.S., 1988-2008," is published online in the current issue of Diabetes Care.
In 1996, the age-adjusted rate of leg and foot amputations was 11.2 per 1,000 individuals with diabetes. However, in 2008 this rate fell to 3.9 per 1,000.
Non-traumatic, lower-limb amputations, refers to amputations caused by circulatory problems, rather than those caused by injuries. Circulatory problems are a prevalent adverse effect in individuals suffering with diabetes.
Furthermore, results from the study revealed that in 2008:

  • Women had lower age-adjusted rates of lower-limb amputations (1.9 per 1,000) than men (6 per 1,000)
  • Individuals aged 75+ had the highest rate (6.2 per 1,000) than people in other age groups
  • Rates were higher among blacks (4.9 per 1,000) than whites (2.9 per 1,000)
According to the researchers, the decrease in lower-limb amputations among individuals with diabetes may partially be due to factors such as: declines in heart disease, improvements in blood sugar control, as well as foot care and diabetes management.
Nilka Ríos Burrows, M.P.H., an epidemiologist with CDC's Division of Diabetes Translation, explained:
"The significant drop in rates of non-traumatic lower-limb amputations among U.S. adults with diagnosed diabetes is certainly encouraging, but more work is needed to reduce the disparities among certain populations.
We must continue to increase awareness of the devastating health complications of diabetes. Diabetes is the leading cause of lower-limb amputations in the United States."

After examining data from the National Hospital Discharge Survey on non-traumatic lower-limb amputations from the National Health Interview Survey on the prevalence of diagnosed diabetes from 1988-2008, the researchers discovered that the decrease in rates was higher among individuals with diagnosed diabetes than people without the disease. Although, in 2008, the rate was still approximately 8 times higher among those with the disease than those without diabetes.
Diabetes is the leading cause of non-traumatic, lower-limb amputations, kidney failure, and blindness among adults. In addition, the disease is the 7th leading cause of mortality in the U.S.. Diabetes also increases the risk of strokes, hypertension, and heart attacks.
CDC's Division of Diabetes Translation supports prevention and control programs in all 50 states, seven U.S. territories and island jurisdictions, and the District of Columbia.
The National Diabetes Education Program provides education to enhance treatment for individuals with the disease, promote early diagnosis and prevent or delay type 2 diabetes from developing. The program is co-sponsored by CDC and the National Institutes of Health.

When Using Oxygen To Regenerate Bone, Timing Is Everything

A research team at Tulane University will report this week that the application of high levels of oxygen to a severed bone facilitates bone regrowth, study results that may one day hold promise for injured soldiers, diabetics and other accident victims.
The results of the Department of Defense-funded study were presented at the American Society for Biochemistry and Molecular Biology annual meeting, held in conjunction with the Experimental Biology conference in San Diego.
"One out of every 200 Americans is an amputee," emphasizes Mimi Sammarco, who led the study at Tulane. "This number is expected to double in the next 40 years and is of particular concern given that amputation injuries have increased considerably due to combat casualties and the increasing amputation issues associated with the rise in diabetes and other related diseases."
The only vertebrate capable of regenerating lost limbs is the salamander, which has been the focus of a number of studies by the laboratory where the work was done. Run by Ken Muneoka, a professor at Tulane's cell and molecular biology department, the lab has been exploring the molecular underpinnings of limb regeneration under various circumstances. The work spearheaded by Sammarco, meanwhile, uses a mouse model.
"While salamanders are able to regenerate entire limbs, rodents, monkeys and humans are only able to regenerate the digit tip after amputation," she explains. "The third phalangeal element, the very end bone on your finger, if you amputate one-third back or anywhere toward the tip, it will grow back. If you go just a fraction of a millimeter closer, it won't. If you amputate in the middle bone, it won't."
Multiple research teams have been trying to figure out what makes that huge difference between regrowth here but no regrowth there. The Tulane lab, in particular, has been investigating which genes are turned on, which proteins are expressed and which molecular activities change at the site of amputation over time.
"What it boils down to is genes (that spur regeneration) don't just turn themselves on. They turn on because something signals them. So I thought, maybe it's oxygen that's turning them on," Sammarco says. "Oxygen is often the primary signal that turns on various genes."
Sammarco used a special incubator to expose a thin bone sample taken from an amputation site to high levels of oxygen. "What we found is that when you expose regenerating bone to 20 percent oxygen, it'll respond very favorably but only at a certain time. If you try it too early, like right after amputation, it doesn't do a whole lot."
The air we breathe is made of about 20 percent oxygen, but that's a lot higher than the level in the body, which is closer to around 6 percent, she explains. "In some areas of injury, the oxygen level is going to go down to 1 percent," because the blood vessels that deliver oxygen to tissue naturally retract after injury. "And maybe we're only talking millimeters or fractions of millimeters. They're naturally contractile."
What to do about the drop in oxygen levels is something of a puzzle for those in the wound-healing field, Sammarco says. Many researchers are trying to figure out how to reinvigorate vasculature and how to oxygenate the wound site.
"There are two opposing fields: We get injured, so we need to drop the oxygen concentration to encourage vasculature. And then there's the other side that says, no, we need to flood it with oxygen to oxygenate the tissue. And neither works particularly well," she admits.
The way Sammarco sees it, maybe it's not an either-or situation: "I think you have to know when to apply each one. It's all about timing. Obviously, there's a sequence in growing things back. And oxygen can push the button that has to be applied at a certain time."
Ultimately, battlefield doctors must be able to assess in what stage a patient is in the spectrum of injury and repair.
"Further on down the line, how do we make that treatable in the field in the middle of the desert? How do you make it portable and usable? There's general public usable and there's where it is going to be most useful, and that's in the field - immediate treatment for a soldier so we can have maximal bone growth down the line."
Sammarco emphasizes that even just partial regeneration of a limb would make a world of difference to any amputee and that soldiers in particular are excellent candidates for rehabilitation, because they are usually in fantastic physical shape.
"They're the fittest people out there. They're not diabetics receiving amputations. They're not the average American who received an amputation after a car crash. These are the most viable people for rehabilitation, and these are the people who can benefit from getting an extra inch of stump length and be able to ski - to do things they were doing before, because their level of activity is so much higher than everybody else's," she says. "Thus, every effort to direct and control the extension of amputation stump length contributes to the rehabilitation of amputees, while keeping in mind the long-term goal of complete regeneration."

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'Protecting' Psychiatric Medical Records Puts Patients At Risk Of Hospitalization 'Switch' Critical to Wound Healing Identified 1811 2013 4 Ways to Beat Back Pain 5 hour energy 500 calories A simple soliloquy a1c AA aarp ablum accessible wheelchair car accessible wheelchair vans acne acne light treatment acting insulin acu acupressure ADD addiction ADHD adolescent victims adults Adults With Diabetes And Limited Health Literacy Less Likely To Adhere To Prescribed Antidepressants advance advise advising afghanistan Aflac Age Matters in Weight Gain: aids airsoft album review Alcoholic Alcoholics Anonymous All IT Supported alltel alzheimers AM General American College of Gastroneterology American Diabetes Association American Express ami clubwear amiclubwear.com amputation android anger animis anniversary anti radiation cell phone technology antibody antidepressants not working anxiety app application apps arginine arthritis artificial artistic aspirin Assurance Wireless asteroid 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diabetic shock diabetic software diabetic supplies diabetic. ebook diamonds diet digital camera digital logbook direct Direct Association Between Type 2 Diabetes And Obesity Found direct tv directionless dirve disability disabled disease disorders Disrupting Our Internal Clocks May Lead To A Complete Absence Of 24-Hour Bodily Rhythms And An Immediate Gain In Body Weight Ditto divorce lawyer diy mouse trap dlucose doctors donation doomsday Doughnuts down range Drexel University drinking drive drop out drug drug abuse drugs dry skin DSHS dvd e-cig e-cigarettes e-juice e-reader e-zines eastern medicine eating disorders ecigarettes Economics education Edward Norton effective treatments egg whites egg yolks electri vehicle electrical stimulation Electronic emergency emergency kit Emma Stone emotional employment empty nest EMR endocrine engraved medical id ereader ev everyone else eviction excess weight exercise exercise regularly exercise routines exterminators eye eye care eye disease eye glasses EyeBuyDirect eyebuydirect.com facebook fad diet fad diets family focused therapy Family Time fashion fatty acids favorite foods FDA feel fuller fire fish oil fitness Fitness Professionals Appreciate Online Continuing Education Options Fitness; Obesity; Diabetes; Molecular Biology; Mice; Biology flights florida Florida health kids program flu food Food and Dining food diary food network foods contain forgetfulness four more years free free android apps free diabetic wristband Free Stuff french fries fresh flowers fresh fruit Fresh Vending Machines fructose fructose corn syrup fruit full moon funeral Gadgets gangnam style Gastroesophageal gastroparesis GE X500 Power Series genes genes linked to bipolar GERD gestational diabetes Gestational Diabetes Patients Will Develop Type 2 Diabetes Give Aways giving glasses glooko glucagon Gluco(M) Glucofact glucose glucose levels glucose log glucose management glucose meter gluten free glycemic control glycemic foods glycemic index glycemic indexes godaddy google gout grain foods green tea group guest blog guest post hair loss handicap accessible vans handicap minivans handicap vans handicapped vans happy Happy Birthday Hello Cupcake It's Me happy birthday to me :) happy holidays Harvey Birdman hba1c health health benefits health care healthier fast food healthy healthy foods healthy lifestyle healthy snack hearing loss heart heart attack heart broken Heart Disease; Cholesterol; Stroke Prevention; Diseases and Conditions; Chronic Illness; Heart Disease; Cholesterol; Stroke Prevention; Diseases and Conditions; Chronic Illness; diabetes Heart Disease; Cholesterol; Stroke Prevention; Diseases and Conditions; Chronic Illness; stroke Heart Disease; Cholesterol; Stroke Prevention; Diseases and Conditions; Chronic Illness; Vioxx heart monitor heart on my sleeve heart problems heart rate heath and beauty hello hellocupcakeitsme.com help hemoglobin Her high blood sugar high school High-Fat Foods May Be A Factor In Glucose Control hiv hiv1 hiv2 hobbytron.com holiday holiday's home security alarms home testing Homeless Homeless Shelter Homer Simpson honda hospitalization Household Income Affects Chronic Disease Control In Kids Humalog Human IPSC Humor Humulin R U-500 hunger hungry hurt on the job hyperglycima hyperglycimic hypertension hypoglycemia hypoglycemic hypoglycemic episode iBGStar Blood Glucose Monitoring System Ice Cream Image improvement including mufa foods infection infested infographic information injury inspriation insulated bag Insulin insulin injections insulin patch insulin pump insulin shot record insurance claims internal medicine Interspecies Transplant investments ios ios 5 iphone iphone 4 its iTunes Iwerkz Foldable Bluetooth Keyboard Review Jenna Mables jewelry joann joann fabric and craft store joint pain Journal of Alzheimer's Disease juwait Keek kenguru ketoacidosis occurs kicking the habbit kid kidcare kids Killings kindle kindle fire kitchen counter kombucha Labor and Industry Lamp;I lantus Late-Life Depression lawyer learning issues legal help Lexapro LG Rumor libido life lifestyle changes light box lincoln Link Between Creativity and Mental Illness Confirmed in Large-Scale Swedish Study Lipohypertrophy living loan Lone Star College Shooting loneliness lose weight losing weight loss plan lost low blood sugar low glucose levels Low income cell phone low income glasses low t low testosterone lower glucose lowering lowering glucose levels Luminaze lung health lyrics lyrics of depression Mainframe Support makeup managing diabetes Manic marijuana market mary lambert Master Card maya angelou Maya Angelou dead at 86 me meal plan meal prepping meals require medflash media / television medicaid Medical medical condition medical help Medical Review Medical Studies medical studies. medicare medicare part d medication medicines meditation melody road memory loss men's health Mental Health mental health issues Menu menu options merry christmas metabolic syndrome metabolism metabolites metersync blue miami Michael Keaton microstimulator military minimum purchases mission d.a.d mission dad Mixed Results On Computer-based Support For Diabetes mobility money money saving moods motivation mourning movie review Movie Reviews music music thearpy musings/thoughts/ideas must have MV-1 n-3 Fatty Acids Nanoparticle Suspension and Ultrasound Deliver Insulin Without Regular Injections natural home remdies natural suppliments need needing help needles needy negative thoughts neil diamond Network/Community networking new app new baby New Jersey's Universtiy of Medicine and Dentistry new medication New smart contact lens could monitor glucose for diabetics Nick Jonas night lights nissan no insulin Nook Tablet BNTV400 Review north aferica nova nordisk Now that the holidays are over obama obama phone obama wins 2012 obese Obesity obituries OCD ODD Oil Pulling Olycap omega-3 onetouch online magazines online medical records optical zoom optical123.com Optimus ERM optogenetics oral health oral hiv test oral swab oraquick overcome depression Oxygen paid marketing pancreas parental depression parkinsons party passing Paula Deen pay attention payday payday advance paying kids to attend school pedometer personal food chart Personal Post pest pests photography pills ping plam beach county Plays poet port townsend positive thoughts Postpartum Depression pot prayer pre-owned pre-school pregnancies pregnancy prepper prepping preschool prescription president prevent complications prices processed foods product Product Review products Progress Project 1811 project rudolph proline promo codes promotional Promotions psoriasis Psy public health publich education purchas questioning quit smoking raisins reaching out real butter real-estate really scare rearrange recipes Record red meat red wine reefer reflux regenerate regular exercise rehab remodel research resistance resource resources retail therapy retinopathy revamp review Reviewing the Vapourlites Blueberry/Strawberry E Juice revitalift rich foods risk roller coaster russia rx s.a.d sadness safe sex safelink Safelink wireless sale salt Sandy Hooks Elementary School Schooting saving money savings scar school School Shooting schooling scrubs for cheap seasonal affective disorder Seattle self diagnosis self help self love self medicating senior resources seo sesame seed oil sex Shindigz Coupon Code Shootings shopping Short story shot record sick side-effects simple tips SIN TAX Site Review skin care skin tags skip meals skipping meals sleep sleep apnea smaller meals smart car smart cars smart phone smoker smokes smoking social media social security sodium software sore throat sores south beach south beach diet spiral notebook sponsored sponsored review sponsored; lawyer; family; legal; issues; sponsored/guest post spot removal. ssi Statin Labels stem cell stock pile stomach pain stoner stop smoking store stress stretch marks study submit submitted substitutions successfully lose weight sugar free sugar levels sugary foods suicidal thoughts suicide Supplementation Of Alternative Fuels Could Protect The Brain During Hypoglycemia support surgery survival systemic inflammation taboo tai chi take out tax tea tech teen teen mental health teens television temporary mood test animals test strips testicle testicular cancer testing testing supplies testosterone thanksgiving the learning company the lines project. #thelinesproject thearpy therapy thought Three Devastating Statistics of Diabetes Medical Malpractice title to write love on her arm tone Tosh.O toxins Tracfone trained professional transaction travel treatment trend diets tribute to my father triglycerides tsa tweets twitter twloha type 3 diabetes type-1 type-2 type-2 diabetes U.S. Medicare Part D Can't Explain North-South Disparities UK News ultra long acting UMDNJ underlying reasons Undiagnosed Pre-Diabetes Highly Prevalent in Early Alzheimer's Disease Study unhealthy unhealthy foods up and coming artist up and down upcoming holidays update uric acid usb value of a dollar vans for handicap vans for handicapped vans for wheel chairs mobility vans vans for wheenchairs vape vapor vapourlites vendor Veterans Day Video violation violence Visa Visiting Your Doctor Following ER Care For Chest Pain Reduces Risk Of Heart Attack vitamin d vitamin deficiency walking walking chart walnuts contain washington water waterski weed week in review Week of learning weigh yourself weighing yourself weight weight loss weight loss chart weight loss goals weight loss plan weight loss program weight loss success weight loss tips weight slowly what is it What Your Skin Says About Your Health wheel chair wheel chair vans wheelchair wheelchair vans where to buy cheap scrubs whipped butter winter blues womens health Work Out workman's compensation workout X-Men x500 xanax Xenotransplantation Young people with diabetes dying due to lack of adequate healthcare Yourtel youtube YouTube Internet Sensations Then and Now

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