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Showing posts with label Heart Disease; Cholesterol; Stroke Prevention; Diseases and Conditions; Chronic Illness;. Show all posts
Showing posts with label Heart Disease; Cholesterol; Stroke Prevention; Diseases and Conditions; Chronic Illness;. Show all posts

American Diet Fuelling Heart Disease And Diabetes Rates In Southeast Asia

As Southeast Asians embrace American fast foods, such as pizza, french fries, hot dogs and hamburgers, more are dying prematurely form coronary heart disease and developing diabetes type 2, researchers from the University of Minnesota School of Public Health and the National University of Singapore reported in the journal Circulation. The authors say that attention should be focused on the impact of behavioral and dietary changes that take place when cultures interact.
The researchers found that Chinese adults who live in Singapore and consume American-style fast foods, on average, twice each week, had a 56% higher risk of dying from heart disease and a 27% greater chance of developing diabetes type 2, compared to their counterparts who never ate American-style junk foods. Those who ate fast foods at least four times per week were 80% more likely to die from coronary heart disease.
Lead author, Andrew Odegaard, Ph.D., M.P.H., said:

"Western style fast food intake in East and Southeast Asia started becoming more prominent in the late 1980s into the 1990s. This provided an avenue to participate in American culture, which is very different from the historical dietary culture of these populations."

When the study participants entered the Singapore Chinese Health Study, they were aged from 45 to 74 years. The study lasted from 1993 to 2009 (16 years). By the end of the study, 1,397 had died from coronary heart disease and 2,252 were newly diagnosed with diabetes.
Researchers used a questionnaire constructed specifically to identify the types of food consumed in the Asian population, looking for 165 different food items that are commonly eaten. Six main fast food items - french fries, pizza, deep fried chicken, hot dogs, hamburgers & cheeseburgers were included, as well 'other fast food sandwiches'.
Western or North American-style fast foods are considered to be unhealthy, due to high content of refined carbohydrates, processed meat and fat. The portions are often large and high in sodium and cholesterol. Those found to be eating these kinds of foods showed a reduced intake of vegetables, dairy, rice, carbohydrates, rice and dietary fiber. To their credit, they were educated, smoked less, and were more likely to be physically active, this profile obviously makes them less likely to have high blood pressure, but nonetheless, this kind of diet doesn't bode well later in life, increasing the risks of cardiovascular problems and type two diabetes amongst other problems.
The constant 'Americanization' of the world continues at a fast pace, with multi-national companies spreading their outlets into developing countries at an increasing rate. The study's author, Odegaard, said that the research indicated that more attention was needed to understand the changes in diet and habits as different cultures interact more with each other.
It's clear that the increasing obesity in North America and Europe is a product of diet and lifestyle and concerns are mounting about looming health implications for future generations, with some predicting an avalanche of type two diabetes and cardiovascular problems over the next few decades. Clearly, this problem is not confined to Caucasians, it's simply a question of cultural and dietary habits that can weigh heavily on the health

Long-Overlooked Protein May Be The Gateway To The Storage And Burning Of Fat, Diabetes Treatment

Humans are built to hunger for fat, packing it on during times of feast and burning it during periods of famine. But when deluged by foods rich in fat and sugar, the modern waistline often far exceeds the need to store energy for lean times, and the result has been an epidemic of diabetes, heart diseaseand other obesity-related problems.
Now, scientists at the Salk Institute for Biological Studies have identified the linchpin of fat metabolism, a protein known as fibroblast growth factor 1 (FGF1), which may open new avenues in the treatment of diabetes.
In a paper published in Nature, the Evans lab reports that FGF1 activity is triggered by a high-fat diet and that mice lacking the protein swiftly develop diabetes. This suggests that FGF1 is crucial to maintaining the body's sensitivity to insulin and normal levels of sugar in the blood.
"Because humans are good at storing fat during times of plenty, we are also excellent at surviving times of famine," says Ronald M. Evans, a professor in Salk's Gene Expression Laboratory and lead author of the paper. "The fat tissues of our body are like batteries, providing us with a steady source of energy when food is scarce. FGF1 governs the expansion and contraction of fat and thus controls the ebb and flow of energy throughout our body."
Obesity rates have soared in the United States in recent decades, with more than one third of U.S. adults and 17 percent of children and adolescents now considered obese, according to the Centers for Disease Control and Prevention.
As the number of overweight people has grown, so too has the incidence of metabolic disease, with nearly 26 million Americans estimated to have obesity-related type 2 diabetes. With annual costs exceeding well over $200 billion, obesity is a chronic disease that is consuming a huge portion of our health care dollars.
Although exercise and calorie restriction are known to be effective at preventing and treating diabetes, the obesity epidemic continues to grow and new drugs to treat the problem are desperately needed. Against this backdrop, the Evans' lab discovery is an important breakthrough - and a surprise.
"The discovery of FGF1 was unexpected - and intriguing - because it was believed to do nothing," says Jae Myoung Suh, a postdoctoral researcher in Evans' laboratory and co-first author on the paper. "If you deplete FGF1 from the body, nothing happens when the mice are fed a steady low fat diet. But when given a high-fat, "Western-style" diet the mice develop an aggressive form of diabetes and experience a system-wide breakdown of their metabolic health."
"These abnormalities cause abdominal or stomach fat to become inflamed," says Michael Downes, a senior staff scientist in Salk's Gene Expression Laboratory and co-lead author on the paper. "This is important because inflamed visceral fat has been linked to heightened risk for diabetes and other obesity-related diseases, such as heart disease and stroke."
The scientists also found that FGF1 is regulated by the antidiabetic drug Actos, which is used to increase the body's sensitivity to insulin. But Actos and related drugs, though helpful, have side effects that limit their use.
Thus, Evans and his colleagues plan to explore whether FGF1 might point to a new way to control diabetes by avoiding the drawbacks of Actos and providing a more natural means of increasing insulin sensitivity.

Higher HbA1c Levels Predict Better Outcomes in Advanced Heart Failure With Diabetes

Patients with advanced heart failure who were also diabetic had better two-year survival if their baseline glycated hemoglobin (HbA1c) levels were >7.3% in a new study [1]. Among the non-diabetic patients with heart failure, HbA1C levels did not predict survival outcomes. The retrospective cohort study is published online March 27, 2012 in the American Journal of Cardiology.

"We're finding that in heart failure [plus diabetes], higher HbA1C levels are associated not with worse outcomes, but with better outcomes," lead investigator Dr Tamara Horwich (University of California, Los Angeles) told heartwire . This suggests that for patients with both diseases, "the focus should not be on lowering the HbA1Clevels to as low as possible," she said, adding that "aiming for a midrange of 7.2% to 8.2% may be very reasonable."

This "adds to a small but growing body of literature demonstrating a complex relationship between levels of glycemic control and survival in patients with advanced, established heart failure," Dr David Aguilar (Baylor College of Medicine, Houston, TX), who was not involved with this research, told heartwire . However, because it was an observational study, residual confounding factors may be contributing to adverse outcomes.

The implications for clinical practice are that "in someone with advanced heart failure who may be having difficulties with hypoglycemia or other adverse effects of diabetic medications, less stringent glycemic control (HbA1C <8%) may be acceptable," he said. On the other hand, "if patients are tolerating the medications without difficulties, current glycemic guidelines should continue to be followed as we await further information from prospective clinical trials."

Very Sick Heart-Failure Patients

In patients with established heart failure, the relationship between HbA1C levels and survival is not clear, the group writes. The Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity (CHARM) program found that as HbA1C levels rose, cardiovascular risk increased. However, in a study of close to 6000 older veterans with heart failure, Aguilar and colleagues reported a U-shaped relationship between HbA1C and survival: optimal survival was seen among patients with "modest" glycemic control--an HbA1C of 7.1% to 7.8%.

Horwich and colleagues performed a retrospective analysis on data from 845 patients with advanced heart failure who had been referred to a cardiomyopathy center for heart transplant or other evaluation from 1999 to 2010. The patients had a mean age of 55 years, and 28% were women.

The team subdivided the cohort into two subgroups, 358 patients with diabetes and 487 patients without diabetes, who were then stratified into quartiles according to baseline HbA1C levels.

The primary end points were death or urgent need for heart transplantation and all-cause mortality at two years. At two years, 181 patients had undergone urgent heart transplantation and 180 patients had died.

Among the patients with diabetes, two-year event-free survival was highest in the two highest quartiles of HbA1C.

Patients With Diabetes: Two-Year Survival Free From Death/Urgent Heart Transplantation

Quartile
HbA1C (%)
2-y survival (%)

1
<6.4
47.9

2
6.5–7.2
41.5

3
7.3–8.5
60.7

4
>8.6
65.3

In the subgroup of patients without diabetes, patients with HbA1C levels of 5.7% to 6.0% had better survival, but this was not statistically significant.

Patients Without Diabetes: Two-Year Survival Free From Death/Urgent Heart Transplantation

Quartile
HbA1c (%)
2-y survival (%)

1
<5.6
50.4

2
5.7–6.0
60.6

3
6.1–6.5
51.1

4
>6.6
49.9

In the total cohort, after adjustment for age, gender, body-mass index, and LVEF, for each unit increase in HbA1C, patients had an 8% decreased risk of death or need for urgent transplantation. In the subgroup of patients with diabetes, for each unit increase in HbA1C, patients had a 15% decreased risk of death or need for urgent transplantation.

Awaiting Further Trials, Individualized Treatment for Now

Low HbA1c levels may reflect an inflammatory state or malnutrition, or some anti-diabetic therapies may be causing the adverse cardiac outcomes, Horwich speculated.

Many, large-scale, phase 3 trials are currently testing the safety and efficacy of diabetic therapies in high-risk patients, including those with heart failure--a group that has often been excluded from glycemia clinical trials--said Aguilar. "Hopefully, we will have more prospective data on the best treatment strategies in this patient population over the next several years. . . . For now, I believe that practicing clinicians should follow published guidelines, which state that target glycemic goals should be individualized."

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optogenetics oral health oral hiv test oral swab oraquick overcome depression Oxygen paid marketing pancreas parental depression parkinsons party passing Paula Deen pay attention payday payday advance paying kids to attend school pedometer personal food chart Personal Post pest pests photography pills ping plam beach county Plays poet port townsend positive thoughts Postpartum Depression pot prayer pre-owned pre-school pregnancies pregnancy prepper prepping preschool prescription president prevent complications prices processed foods product Product Review products Progress Project 1811 project rudolph proline promo codes promotional Promotions psoriasis Psy public health publich education purchas questioning quit smoking raisins reaching out real butter real-estate really scare rearrange recipes Record red meat red wine reefer reflux regenerate regular exercise rehab remodel research resistance resource resources retail therapy retinopathy revamp review Reviewing the Vapourlites Blueberry/Strawberry E Juice revitalift rich foods risk roller coaster russia rx s.a.d sadness safe sex safelink Safelink wireless sale salt Sandy Hooks Elementary School Schooting saving money savings scar school School Shooting schooling scrubs for cheap seasonal affective disorder Seattle self diagnosis self help self love self medicating senior resources seo sesame seed oil sex Shindigz Coupon Code Shootings shopping Short story shot record sick side-effects simple tips SIN TAX Site Review skin care skin tags skip meals skipping meals sleep sleep apnea smaller meals smart car smart cars smart phone smoker smokes smoking social media social security sodium software sore throat sores south beach south beach diet spiral notebook sponsored sponsored review sponsored; lawyer; family; legal; issues; sponsored/guest post spot removal. ssi Statin Labels stem cell stock pile stomach pain stoner stop smoking store stress stretch marks study submit submitted substitutions successfully lose 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